化工社化工社 化学情報印刷レポート · 研究参考用
Benzyl Bromide → Boc-DTrp-OBzl
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzyl Bromide | HCID 7498 | — |
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | N-((tert-Butoxy)carbonyl)-D-tryptophan | HCID 111050 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | Boc-DTrp-OBzl | HCID 10739405 | 95% |
反応手順
To an ice-cooled solution of Boc-D-Trp-OH (8.61 g) in DMF (100 ml) were added benzyl bromide (7.19 g) and diisopropylethylamine (4.02 g). The solution was stirred for two hours at the same temperature and overnight at room temperature. After evaporation, the residue was extracted with ethyl acetate. The organic layer was washed successively with water, sodium hydrogencarbonate solution, 0.5 hydrochlolic acid, and sodium chloride solution, and dried over magnesium sulfate. Evaporation gave Boc-D-Trp-OBzl (10.6 g) as a crystalline mass.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05187156 |
| 出典データセット | uspto-grants-1993_02 |
| ORD ID | ord-b08df90ed268472484e2250dbf5f4ea9 |
| 出典メモ | uspto-grants-1993_02 |