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Hydrochloric Acid → Boc-D-Trp(Tos)-OBzl
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 4-Toluenesulfonyl chloride | HCID 7397 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Boc-DTrp-OBzl | HCID 10739405 | — |
| 触媒 | Ethanaminium, N,N,N-trimethyl-, chloride (1:1) | HCID 33992 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | Boc-D-Trp(Tos)-OBzl | HCID 131717761 | 116.1% |
反応手順
Boc-D-Trp-OBzl (2.0 g) and ethyltrimethylammonium chloride (16.2 mg) were dissolved in methylene chloride (30 ml), and powdered sodium hydroxide (507 mg) was added. To this mixture was added a solution of Tos-Cl (1.45 g) in methylene chloride (5 ml) at room temperature. The reaction mixture was stirred for three and half an hour. After addition of 1N-hydrochloric acid (7.5 ml), the organic layer was separated, washed with sodium chloride solution, dried over magnesium sulfate, and evaporated to give Boc-D-Trp(Tos)-OBzl as an oil (3.23 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05187156 |
| 出典データセット | uspto-grants-1993_02 |
| ORD ID | ord-bca4c39040b84e01aa0e7df0d94e2915 |
| 出典メモ | uspto-grants-1993_02 |