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Ethyl 1,2-dimethyl-1H-indole-3-carboxylate → (S)-1-[(1-azabicyclo[2.2.2]oct-3-yl)aminocarbonyl]-6,7,8,9-tetrahydropyrido[1,2-a]indole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl 1,2-dimethyl-1H-indole-3-carboxylate | HCID 599139 | — |
| 反応物 | (S)-quinuclidin-3-amine | HCID 719216 | — |
| 反応物 | Methyl 6,7,8,9-tetrahydropyrido[1,2-a]indole-1-carboxylate | HCID 19778122 | — |
| 生成物 | (S)-1-[(1-azabicyclo[2.2.2]oct-3-yl)aminocarbonyl]-6,7,8,9-tetrahydropyrido[1,2-a]indole | HCID 53857764 | 82% |
反応手順
Proceeding as in Example 2, Method B, but replacing (RS)-3-amino-1-azabicyclo[2.2.2]octane with (S)-3-amino-1-azabicyclo[2.2.2]octane and ethyl 1,2-dimethylindole-3-carboxylate with methyl 6,7,8,9-tetrahydropyrido[1,2-a]indole-1-carboxylate, from Example 1, there was prepared (S)-1-[(1-azabicyclo[2.2.2]oct-3-yl)aminocarbonyl]-6,7,8,9-tetrahydropyrido[1,2-a]indole (82% yield), m.p. 163°-164° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05189041 |
| 出典データセット | uspto-grants-1993_02 |
| ORD ID | ord-1934814f546f477287fd064d9dcbaca1 |
| 出典メモ | uspto-grants-1993_02 |