Hydrochloric Acid → benzyl L-alanyl-D-isoglutaminate hydrochloride
反応式
C(OC([NH:8][C@H:9]([C:11]([NH:13][C@@H:14]([C:27](=[O:29])[NH2:28])[CH2:15][CH2:16][C:17]([O:19][CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)=[O:18])=[O:12])[CH3:10])=O)(C)(C)C.[ClH:30].CCOCC>C(OCC)(=O)C>[ClH:30].[NH2:8][C@H:9]([C:11]([NH:13][C@@H:14]([C:27](=[O:29])[NH2:28])[CH2:15][CH2:16][C:17]([O:19][CH2:20][C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1)=[O:18])=[O:12])[CH3:10]参加物
5
実験手順
To 0.406 g of benzyl t-butyloxycarbonyl-L-alanyl-D-isoglutaminate (7, n = 2, X1 = L-alanyl) at 22° C there is added 5 ml of a saturated solution of hydrogen chloride in ethyl acetate. After 10 minutes, 40 ml of ether is added and the precipitated salt is collected by centrifugation and carefully dried in vacuo to give 0.325 g of benzyl L-alanyl-D-isoglutaminate hydrochloride (10, n = 2, X1 = L-alanyl).