HCID 12793272、化合物 → HCID 12793261、化合物
反応式
[O:1]=[C:2]1[NH:7][C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[O:14][CH2:15][CH:16]=[CH2:17])=[N:5][CH:4]=[C:3]1[C:18]([NH2:20])=O>P(Cl)(Cl)(Cl)=O>[O:1]=[C:2]1[NH:7][C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[O:14][CH2:15][CH:16]=[CH2:17])=[N:5][CH:4]=[C:3]1[C:18]#[N:20]参加物
3
実験手順
A solution of 1,6-dihydro-6-oxo-2-(2-allyloxyphenyl)pyrimidine-5-carboxamide (3.58 g.) in phosphorus oxychloride (60 ml.) was heated under reflux for 2 hours. The solution was evaporated to dryness. The residue was cooled in ice and then treated cautiously with ice-water. The mixture was warmed to 25° and then heated on a steam bath for 15 minutes. The solid was collected, washed with cold water, and recrystallized from benzene-Skellysolve B to give the title compound (2.3 g., 69%), m.p. 162°-164°.
後処理
- temperatureunder reflux for 2 hours
- customThe solution was evaporated to dryness