Acetic Anhydride → Aurone

HRID 2082999ノート

反応式

HRID 2082999 の反応式
[O:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3](=[O:10])[CH2:2]1.C(O[C:15](=O)[CH3:16])(=O)C>>[CH:4]1[CH:5]=[CH:6][C:15](/[CH:16]=[C:2]2/[C:3]([C:4]3[C:9]([O:1]/2)=[CH:8][CH:7]=[CH:6][CH:5]=3)=[O:10])=[CH:2][CH:3]=1

参加物

3

反応物 2

HCID 7918Acetic AnhydrideHCID 23556Coumaranone

生成物 1

HCID 6537099Aurone

反応条件

温度
100 °C

実験手順

The compounds of this invention are prepared as shown in the following reaction scheme: ##STR2## in which R1 and R2 are as defined in formula I. Thus, as shown above, a 3-coumaranone is reacted with an appropriately substituted benzaldehyde and acetic anhydride by heating at a temperature up to about 100° C. for from 1 to 3 hours. The reaction mixture is treated with ice, extracted with a nonreactive organic solvent such as ether and the product from the extract is heated at reflux for about one hour with a mineral acid, such as hydrochloric acid, an alkanol such as methanol or ethanol, and water. Cooling gives the substituted aurone product.

後処理

  1. customThe compounds of this invention are prepared
  2. customas shown in the following reaction scheme
  3. additionThe reaction mixture is treated with ice
  4. extractionextracted with a nonreactive organic solvent such as ether
  5. temperaturethe product from the extract is heated
  6. temperatureat reflux for about one hour with a mineral acid, such as hydrochloric acid
  7. temperatureCooling

出典と根拠

ORDレコード
ord-2f571148c8404e2085cbc77c11b8835e
出典データセット
uspto-grants-1978_04
特許番号
US04083952

反応ノート

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