Pinacolone → HCID 86735615、化合物

反応式

CC(C(C)(C)C)=O.[C:8]([C:12]([CH:14]=[O:15])=O)([CH3:11])([CH3:10])[CH3:9].CC(=[N:19][OH:20])C>>[C:8]([C:12](=[N:19][OH:20])[CH:14]=[O:15])([CH3:11])([CH3:10])[CH3:9]

参加物

反応物 3

HCID 6416Pinacolone

HCID 67180Acetone, oxime

HCID 3499723,3-Dimethyl-2-oxobutanal2 回

生成物 1

HCID 86735615HCID 86735615、化合物

実験手順

Yet another oxime intermediate is prepared from t-butyl methyl ketone, which is first transformed into t-butylglyoxal using the procedure of Fuson et al., J. Am. Chem. Soc. 61, 1938 (1939). The t-butylglyoxal, in aqueous solution at pH 4-5, is allowed to react with acetone oxime (commercially available) at about room temperature for about two days. The reaction product mixture is worked up by extracting it with ether, and the t-butylglyoxal oxime is isolated from the ether extract as colorless needles having a melting point of about 50°-52° C.