Water → Acetic acid-2-(3-cyanopropyl)-benzyl ester

HRID 2083110ノート

反応式

HRID 2083110 の反応式
[C-:1]#[N:2].[Na+].Cl[CH2:5][CH2:6][CH2:7][C:8]1[CH:18]=[CH:17][CH:16]=[CH:15][C:9]=1[CH2:10][O:11][C:12](=[O:14])[CH3:13].O.CCOCC>CS(C)=O>[C:1]([CH2:5][CH2:6][CH2:7][C:8]1[CH:18]=[CH:17][CH:16]=[CH:15][C:9]=1[CH2:10][O:11][C:12](=[O:14])[CH3:13])#[N:2]

参加物

6

反応物 4

HCID 962WaterHCID 3283Diethyl EtherHCID 8929Sodium CyanideHCID 20322157HCID 20322157、化合物

生成物 1

HCID 20322111Acetic acid-2-(3-cyanopropyl)-benzyl ester

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒

実験手順

With exclusion of humidity 12.5 g (0.25 mol) of dry NaCN were heated in 65 ml of anhydrous DMSO to 90° C and at this temperature 44.8 g (0.2 mol) of acetic acid-2-(3-chloropropyl)-benzyl ester were added dropwise. Then the mixture was heated for 50 minutes to 120° C and distributed after cooling between water and ether. The aqueous phase was extracted three times with ether, the organic phase was washed three times with a saturated sodium chloride solution, dried and concentrated under reduced pressure. The product boiled at 128° C/0.2 mm mercury.

後処理

  1. additionwere added dropwise
  2. temperatureThen the mixture was heated for 50 minutes to 120° C
  3. extractionThe aqueous phase was extracted three times with ether
  4. washthe organic phase was washed three times with a saturated sodium chloride solution
  5. customdried
  6. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-c49b7bf960114e94831a8839a55d46f0
出典データセット
uspto-grants-1978_04
特許番号
US04083990

反応ノート

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