Benzaldehyde → 4-Piperidinone, 3,5-bis(phenylmethylene)-, hydrochloride

HRID 2083189ノート

反応式

HRID 2083189 の反応式
C([N:4]1[CH2:9][CH2:8][C:7](=[O:10])[CH2:6][CH2:5]1)(=O)C.[CH:11](=O)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.[ClH:19]>C(O)C>[ClH:19].[C:12]1([CH:11]=[C:8]2[C:7](=[O:10])[C:6](=[CH:11][C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[CH2:5][NH:4][CH2:9]2)[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

参加物

5

反応物 3

HCID 240BenzaldehydeHCID 313Hydrochloric AcidHCID 122563N-Acetyl-4-piperidone

生成物 1

HCID 3557494-Piperidinone, 3,5-bis(phenylmethylene)-, hydrochloride

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 14 g. (0.1 mole) of N-acetyl-4-piperidinone and 32 g. (0.3 mole) of benzaldehyde in 150 ml. of ethanol containing 33 ml. of conc. HCl is refluxed for 6 hours and then kept overnight at room temperature. The light yellow solid is filtered, washed with ethanol, washed with ether, and air-dried to yield 26 g. of product; m.p. 273°-275° (dec.).

後処理

  1. additionA mixture of 14 g
  2. filtrationThe light yellow solid is filtered
  3. washwashed with ethanol
  4. washwashed with ether
  5. customair-dried
  6. customto yield 26 g

出典と根拠

ORDレコード
ord-2acf33d8cbda49658623bf6c4d2bb6e2
出典データセット
uspto-grants-1978_04
特許番号
US04085102

反応ノート

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