Dimethylformamide → 1-(3-Cyano-4-oxo-4H-1-benzopyran-6-yl)ethyl acetate

HRID 2083227ノート

反応式

HRID 2083227 の反応式
Br[CH:2]([C:4]1[CH:5]=[CH:6][C:7]2[O:12][CH:11]=[C:10]([C:13]#[N:14])[C:9](=[O:15])[C:8]=2[CH:16]=1)[CH3:3].[C:17]([O-:20])(=[O:19])[CH3:18].[Na+].CN(C)C=O>O>[C:17]([O:20][CH:2]([C:4]1[CH:5]=[CH:6][C:7]2[O:12][CH:11]=[C:10]([C:13]#[N:14])[C:9](=[O:15])[C:8]=2[CH:16]=1)[CH3:3])(=[O:19])[CH3:18]

参加物

5

反応物 3

HCID 6228DimethylformamideHCID 517045Sodium AcetateHCID 203582246-(1-Bromoethyl)-4-oxo-4H-1-benzopyran-3-carbonitrile

生成物 1

HCID 203582201-(3-Cyano-4-oxo-4H-1-benzopyran-6-yl)ethyl acetate

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
70 °C

実験手順

A mixture of 5.56 parts of 6-(1-bromoethyl)-4-oxo-4H-1-benzopyran-3-carbonitrile, 1.640 parts of anhydrous sodium acetate and 8 parts by volume of dimethylformamide is heated at 70° C under stirring for 50 minutes. After cooling, the reaction mixture is poured into 100 parts by volume of water to give precipitates, which are collected and recrystallized from ethanol and subsequently ethyl acetate. The procedure yields 2.90 parts of 6-(1-acetoxy-ethyl)-4-oxo-4H-1-benzopyran-3-carbonitrile. Melting point: 148°-149° C

後処理

  1. temperatureAfter cooling
  2. customto give
  3. customprecipitates
  4. customwhich are collected
  5. customrecrystallized from ethanol and subsequently ethyl acetate

出典と根拠

ORDレコード
ord-1f04cdfe96ca4084b6c7976e3ff36443
出典データセット
uspto-grants-1978_04
特許番号
US04085116

反応ノート

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