Pyridinium chloride → 2-(2-Chloroallyl)-2-methyl-5-hydroxy-6,7-dichloro-1-indanone

HRID 2083468ノート

反応式

HRID 2083468 の反応式
[CH3:1][C:2]1([CH2:16][C:17]#[CH:18])[CH2:10][C:9]2[C:4](=[C:5]([Cl:14])[C:6]([Cl:13])=[C:7]([O:11]C)[CH:8]=2)[C:3]1=[O:15].[ClH:19].N1C=CC=CC=1>O>[Cl:19][C:17](=[CH2:18])[CH2:16][C:2]1([CH3:1])[CH2:10][C:9]2[C:4](=[C:5]([Cl:14])[C:6]([Cl:13])=[C:7]([OH:11])[CH:8]=2)[C:3]1=[O:15]

参加物

4

反応物 2

HCID 10176127Pyridinium chlorideHCID 203584432-Methyl-2-propargyl-5-methoxy-6,7-dichloro-1-indanone

生成物 1

HCID 203584572-(2-Chloroallyl)-2-methyl-5-hydroxy-6,7-dichloro-1-indanone

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
185 °C

実験手順

A stirred mixture of 2-methyl-2-propargyl-5-methoxy-6,7-dichloro-1-indanone (11 g., 0.039 mole) and pyridine hydrochloride (110 g.) is heated at 185° C. for one hour, then poured into water (500 ml.). The product which separates is recrystallized from ethanol-water affording 6.5 g. of 2-(2-chloroallyl)-2-methyl-5-hydroxy-6,7-dichloro-1-indanone, m.p. 183° C.

後処理

  1. customThe product which separates is recrystallized from ethanol-water affording 6.5 g

出典と根拠

ORDレコード
ord-bcd71e29b3094d4e891228c3440b6988
出典データセット
uspto-grants-1978_04
特許番号
US04085219

反応ノート

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