化工社化工社 化学情報印刷レポート · 研究参考用
Oxalyl chloride → 2-Methoxy-4,6-bis(trifluoromethyl)benzoyl chloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Oxalyl chloride | HCID 65578 | — |
| 反応物 | 2-Methoxy-4,6-bis(trifluoromethyl)benzoic acid | HCID 2741287 | — |
| 触媒 | Dimethylformamide | HCID 6228 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 2-Methoxy-4,6-bis(trifluoromethyl)benzoyl chloride | HCID 17999345 | 109.3% |
反応手順
To a solution of 2-(methyloxy)-4,6-bis(trifluoromethyl)benzoic acid (20.2 g; 70.14 mmol) in dry DCM (400 mL), at 0° C., was added dropwise oxalyl chloride (13.4 mL; 154.31 mmol) followed by dry DMF (5 drops). The reaction was allowed to reach room temperature. After overnight stirring the solvent was evaporated in vacuo to get the title product (23.5 g) as a yellow slurry used without further purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07745642B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-865399f9efde4960829c7c9e0ae9bec4 |
| 出典メモ | uspto-grants-2010_06 |