2-Chloro-3-methoxypropionaldehyde → HCID 20357035、化合物

The dimethyl acetal of 2-chloro-3-methoxypropionaldehyde (0.1 mole) and toluene (75 ml) are charged into a glass reaction vessel equipped with a mechanical stirrer, thermometer and reflux condenser. Chloromethylamine (0.22 mole) is added to the reaction mixture with stirring at room temperature. Stirring is continued for a period of about 15 minutes. After this time the reaction mixture is heated at reflux for a period of about 1 hour. The reaction mixture is then cooled to room temperature and filtered. The filtrate is stripped of toluene and unreacted starting material under reduced pressure to yield the desired product the dimethyl acetal of 2-chloromethylamino-3-methoxypropionaldehyde as the residue.

1. customequipped with a mechanical stirrer
2. temperaturethermometer and reflux condenser
3. stirringStirring
4. temperatureAfter this time the reaction mixture is heated
5. temperatureat reflux for a period of about 1 hour
6. temperatureThe reaction mixture is then cooled to room temperature
7. filtrationfiltered

ORDレコード

ord-b2a5df402f3f4d0eba15e96054688847

出典データセット

uspto-grants-1978_04

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US04086238