関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Propionic Acid | HCID 1032 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 9H-Xanthen-9-ol, 2-chloro-9-(1-methyl-4-piperidinyl)- | HCID 11809663 | — |
| 反応物 | Sulphobenzoic anhydride | HCID 13795534 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 4-(2-Chloro-9-xanthenylidene)-1-methylpiperidine maleate | HCID 70613469 | — |
反応手順
A mixture of 12.5 g. (0.038 m.) of the xanthene-9-ol, 14.0 g. (0.76 m.) of o-sulfobenzoic anhydride and 380 ml. of propionic acid is refluxed for three hours. The reaction mixture is heated in vacuo at 100° C. and the resulting syrup is dissolved in water, made strongly basic with 40% sodium hydroxide solution, extracted with ether, and the dried extract is evaporated. The residual free base is dissolved in ethyl acetate and maleic acid (4.4 g.) is added to yield 4-(2-chloro-9-xanthenylidene)-1-methylpiperidine maleate, m.p. 206°-207° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04086350 |
|---|
| 出典データセット | uspto-grants-1978_04 |
|---|
| ORD ID | ord-2c4b050a73984c9c8316ee23d073ec72 |
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| 出典メモ | uspto-grants-1978_04 |
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