HCID 178479460、化合物 → HCID 178479458、化合物

HRID 2083832ノート

反応式

HRID 2083832 の反応式
[ClH:1].C(OC([NH:12][C@H:13]([C:21]([N:23]1[CH2:34][CH2:33][CH2:32][C@H:24]1[C:25]([NH:27][CH2:28][C:29]([NH2:31])=[O:30])=[O:26])=[O:22])[CH2:14][CH2:15][CH2:16][NH:17][C:18](=[NH:20])[NH2:19])=O)C1C=CC=CC=1>CO>[ClH:1].[NH2:12][C@H:13]([C:21]([N:23]1[CH2:34][CH2:33][CH2:32][C@H:24]1[C:25]([NH:27][CH2:28][C:29]([NH2:31])=[O:30])=[O:26])=[O:22])[CH2:14][CH2:15][CH2:16][NH:17][C:18](=[NH:19])[NH2:20]

参加物

3

反応物 1

HCID 178479460HCID 178479460、化合物

生成物 1

HCID 178479458HCID 178479458、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Nα -Benzyloxycarbonyl-L-arginyl-L-prolyl-glycinamide hydrochloride, (Example 1, part m) 1.2 g., is dissolved in 60 ml. of absolute methanol, treated with 380 mg. of 10% palladium-on-carbon and the flask flushed with nitrogen, then with hydrogen and the reduction carried out for 40 minutes. Completion of the reaction is determined by thin layer chromatography. The mixture is filtered to separate the catalyst and the filtrate is evaporated and dried under reduced pressure to yield L-arginyl-L-prolyl-glycinamide hydrochloride.

後処理

  1. dissolution, is dissolved in 60 ml
  2. customof 10% palladium-on-carbon and the flask flushed with nitrogen
  3. filtrationThe mixture is filtered
  4. customto separate the catalyst
  5. customthe filtrate is evaporated
  6. customdried under reduced pressure

出典と根拠

ORDレコード
ord-80f43f592b9f42b69472853689d5419c
出典データセット
uspto-grants-1978_04
特許番号
US04086219

反応ノート

読み込み中…