Potassium Carbonate → 1-[4-(4-benzyloxyphenyl)butyl)-1H-1,2,3-triazole

HRID 2084370ノート

反応式

HRID 2084370 の反応式
I[CH2:2][CH2:3][CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[CH:8][CH:7]=1.[NH:20]1[CH:24]=[CH:23][N:22]=[N:21]1.C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[CH2:13]([O:12][C:9]1[CH:10]=[CH:11][C:6]([CH2:5][CH2:4][CH2:3][CH2:2][N:20]2[CH:24]=[CH:23][N:22]=[N:21]2)=[CH:7][CH:8]=1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 22259342Benzyl 4-(4-iodobutyl)phenyl etherHCID 178418936HCID 178418936、化合物

生成物 1

HCID 227333491-[4-(4-benzyloxyphenyl)butyl)-1H-1,2,3-triazole収率 42.4%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
70 °C

実験手順

Benzyl 4-(4-iodobutyl)phenyl ether (1.1 g), 1H-1,2,3-triazole (0.31 g), and potassium carbonate (0.622 g) were suspended in DMF (7.5 ml), followed by stirring at 70° C. for 26.5 hours. After cooling, the reaction mixture was extracted with ethyl acetate and washed with water and saturated saline. Under reduced pressure, the solvent was distilled off; the residue was subjected to silica gel column chromatography (eluent: hexane-ethyl acetate=4:1→2:3) to yield the titled compound (0.391 g).

後処理

  1. temperatureAfter cooling
  2. extractionthe reaction mixture was extracted with ethyl acetate
  3. washwashed with water and saturated saline
  4. distillationUnder reduced pressure, the solvent was distilled off

出典と根拠

ORDレコード
ord-4017f839441f42908f0a339695075be8
出典データセット
uspto-grants-2004_04
特許番号
US06716863B2

反応ノート

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