Ethyl pyruvate → 4-amino-6-methyl-7(8H)-pteridone

HRID 2084571

反応式

HRID 2084571 の反応式
[NH2:1][C:2]1[C:7]([NH2:8])=[C:6]([NH2:9])[N:5]=[CH:4][N:3]=1.[C:10](OCC)(=[O:14])[C:11]([CH3:13])=O>C(O)(=O)C>[NH2:1][C:2]1[C:7]2[N:8]=[C:11]([CH3:13])[C:10](=[O:14])[NH:9][C:6]=2[N:5]=[CH:4][N:3]=1

参加物

4

反応物 2

HCID 12041Ethyl pyruvateHCID 670494,5,6-Pyrimidinetriamine

生成物 1

HCID 101302034-amino-6-methyl-7(8H)-pteridone

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

More specifically, with reference to FIG. 2, 4,5,6-triaminopyrimidine (1), (see, J. Baddiley et al., J. Chem. Soc. 386 (1943)) and ethyl pyruvate are heated in glacial acetic acid for 2 hours. After cooling the precipitate is collected and washed with water and purified by recrystallization using a suitable solvent system, such as DMF/H2O, to yield 4-amino-6-methyl-7(8H)-pteridone (3) (see, D. Söll et al., Chem. Ber. 96:2977 (1963)). Compounds wherein R1 is an methyl group can be generated similarly by starting with 4,5,triamino-2-methylpyrimidine (2).

後処理

  1. temperatureAfter cooling the precipitate
  2. customis collected
  3. washwashed with water
  4. custompurified by recrystallization

出典と根拠

ORDレコード
ord-36969aaaa3724d5aa4a4083a2d3f88a3
出典データセット
uspto-grants-2004_04
特許番号
US06716971B1

関連ノート

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