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Hydrochloric Acid → 6-Methyl-2-(trifluoroacetyl)tetralone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Ethyl trifluoroacetate | HCID 9794 | — |
| 反応物 | 3,4-dihydro-6-methylnaphthalen-1(2H)-one | HCID 162620 | — |
| 反応物 | Sodium Methoxide | HCID 10942334 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | 6-Methyl-2-(trifluoroacetyl)tetralone | HCID 22315552 | 85.1% |
反応手順
Ethyl trifluoroacetate (5.33 g, 37.5 mmol) was dissolved in ether (50 mL) and treated with a sodium methoxide solution (25% in mechanol, 9.92 g, 45.9 mmol) followed by 6-methyltetralone (5.94 g, 37.1 mmol). The reaction was stirred at room temperature for 6.1 hours then treated with 3N HCl (20 mL). The organic layer was collected, washed with brine, dried over MgSO4, and concentrated in vacuo to give a brown oil (8.09 g) that was used in the next step without further purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06716991B1 |
| 出典データセット | uspto-grants-2004_04 |
| ORD ID | ord-fc85676a2de341f9a90fdb5d8f2e28fc |
| 出典メモ | uspto-grants-2004_04 |