Acetic Acid → 2-Cyano-7-methoxybenzofuran-4-carboxylic acid

HRID 2084816ノート

反応式

HRID 2084816 の反応式
[C:1]([C:3]1[O:4][C:5]2[C:6](=[C:8]([CH:14]=[O:15])[CH:9]=[CH:10][C:11]=2[O:12][CH3:13])[CH:7]=1)#[N:2].C(O)(=[O:18])C.S(=O)(=O)(O)N.Cl([O-])=O.[Na+]>O>[C:1]([C:3]1[O:4][C:5]2[C:6](=[C:8]([C:14]([OH:18])=[O:15])[CH:9]=[CH:10][C:11]=2[O:12][CH3:13])[CH:7]=1)#[N:2]

参加物

6

反応物 4

HCID 176Acetic AcidHCID 5987Sulfamic AcidHCID 227342992-Cyano-7-methoxybenzofuran-4-carbaldehydeHCID 23668197Sodium Chlorite

生成物 1

HCID 227341122-Cyano-7-methoxybenzofuran-4-carboxylic acid

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of Compound IIi (0.2 g) obtained in Reference Example 9, a 80% aqueous solution (2 ml) of acetic acid, sulfamic acid (0.145 g), and a 80% aqueous solution (0.084 g) of sodium chlorite was stirred at room temperature one night. The mixture was diluted with water, and then the precipitated solid was collected by filtration and dried to give Compound IIab (0.259 g, 83%) as white crystals.

後処理

  1. customobtained in Reference Example 9
  2. filtrationthe precipitated solid was collected by filtration
  3. customdried
  4. customto give Compound IIab (0.259 g, 83%) as white crystals

出典と根拠

ORDレコード
ord-2e13650f45cf4fb1875be7e20ba527b4
出典データセット
uspto-grants-2004_04
特許番号
US06716987B1

反応ノート

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