Hydrochloric Acid → 7-Methoxy-1-benzofuran-2-carbaldehyde
反応式
[C:1]([C:3]1[O:4][C:5]2[C:11]([O:12][CH3:13])=[CH:10][CH:9]=[CH:8][C:6]=2[CH:7]=1)#N.CC(C[AlH]CC(C)C)C.C[OH:24].Cl>ClCCl.C1(C)C=CC=CC=1>[CH3:13][O:12][C:11]1[C:5]2[O:4][C:3]([CH:1]=[O:24])=[CH:7][C:6]=2[CH:8]=[CH:9][CH:10]=1参加物
7
実験手順
2-Cyano-7-methoxybenzofuran (0.736 g) was dissolved in dichloromethane (10 ml), and a 1.02N DIBAL solution (5.4 ml) in toluene was added thereto at −4 to −30° C., followed by stirring for one hour. Methanol and dilute hydrochloric acid were added to the mixture, and the solvent was distilled off. The obtained residue was purified by column chromatography (hexane/ethyl acetate=10/1) to give Compound IIad-a (0.371 g, 50%) as an oily substance.
後処理
- customat −4 to −30° C.
- distillationthe solvent was distilled off
- customThe obtained residue was purified by column chromatography (hexane/ethyl acetate=10/1)
- customto give Compound IIad-a (0.371 g, 50%) as an oily substance
出典と根拠
- ORDレコード
- ord-5aa010a527b04073ac73dff28f5bb7a3
- 出典データセット
- uspto-grants-2004_04
- 特許番号
- US06716987B1
反応ノート
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