Boron tribromide → 2-(5-Ethylthiophen-2-yl)-4-hydroxybenzo(b)furan

反応式

[CH2:1]([C:3]1[S:7][C:6]([C:8]2[O:12][C:11]3[CH:13]=[CH:14][CH:15]=[C:16]([O:17]C)[C:10]=3[CH:9]=2)=[CH:5][CH:4]=1)[CH3:2].B(Br)(Br)Br>>[CH2:1]([C:3]1[S:7][C:6]([C:8]2[O:12][C:11]3[CH:13]=[CH:14][CH:15]=[C:16]([OH:17])[C:10]=3[CH:9]=2)=[CH:5][CH:4]=1)[CH3:2]

参加物

反応物 2

HCID 25134Boron tribromide

HCID 227293132-(5-Ethylthiophen-2-yl)-4-methoxybenzo(b)furan

生成物 1

HCID 227292262-(5-Ethylthiophen-2-yl)-4-hydroxybenzo(b)furan収率 81.8%

実験手順

By the reactions in the same manner as in Starting Material Synthesis Example 5 using 2-(5-ethylthiophen-2-yl)-4-methoxybenzo(b)furan (1.00 g) and boron tribromide (1.0 ml), the title compound (774 mg) was obtained as colorless crystals, melting point 87-90° C.

出典と根拠

ORDレコード: ord-3173b9762e0e408696997e5bc27e41f5
出典データセット: uspto-grants-2004_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06720320B2

反応ノート

読み込み中…