Potassium Carbonate → (s)-2-(5-Ethylthiophen-2-yl)-4-glycidyloxybenzo(b)furan

HRID 2085182ノート

反応式

HRID 2085182 の反応式
[CH2:1]([C:3]1[S:7][C:6]([C:8]2[O:12][C:11]3[CH:13]=[CH:14][CH:15]=[C:16]([OH:17])[C:10]=3[CH:9]=2)=[CH:5][CH:4]=1)[CH3:2].S(C1C=CC([N+]([O-])=O)=CC=1)(O[CH2:22][C@H:23]1[O:25][CH2:24]1)(=O)=O.C(=O)([O-])[O-].[K+].[K+]>>[CH2:1]([C:3]1[S:7][C:6]([C:8]2[O:12][C:11]3[CH:13]=[CH:14][CH:15]=[C:16]([O:17][CH2:22][C@H:23]4[O:25][CH2:24]4)[C:10]=3[CH:9]=2)=[CH:5][CH:4]=1)[CH3:2]

参加物

4

反応物 3

HCID 11430Potassium CarbonateHCID 10868995(S)-(+)-Glycidyl-4-nitrobenzoateHCID 227292262-(5-Ethylthiophen-2-yl)-4-hydroxybenzo(b)furan

生成物 1

HCID 60078009(s)-2-(5-Ethylthiophen-2-yl)-4-glycidyloxybenzo(b)furan

実験手順

By the reactions in the same manner as in Starting Material Synthesis Example 1 using 2-(5-ethylthiophen-2-yl)-4-hydroxybenzo(b)furan (750 mg), (S)-glycidyl nosylate (875 mg) and potassium carbonate (1.27 g), a crude product of the title compound was quantitatively obtained as a yellow oil.

出典と根拠

ORDレコード
ord-63da676dd8884166bd1486941c934b84
出典データセット
uspto-grants-2004_04
特許番号
US06720320B2

反応ノート

読み込み中…