HCID 22282607、化合物 → HCID 22282614、化合物

HRID 2085340ノート

反応式

HRID 2085340 の反応式
[O:1]=[S:2]1(=[O:22])[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[C:5]([C:12]2[CH:21]=[CH:20][C:15]([C:16]([O:18][CH3:19])=[O:17])=[CH:14][CH:13]=2)=[CH:4][CH2:3]1>CO>[O:1]=[S:2]1(=[O:22])[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[CH:5]([C:12]2[CH:21]=[CH:20][C:15]([C:16]([O:18][CH3:19])=[O:17])=[CH:14][CH:13]=2)[CH2:4][CH2:3]1

参加物

3

反応物 1

HCID 22282607HCID 22282607、化合物

生成物 1

HCID 22282614HCID 22282614、化合物収率 73%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Methyl 4-(1,1-dioxido-2H-1-benzothiopyran-4-yl)benzoate from reaction 33c (0.64 g, 2.13 mmol) was dissolved in methanol (30 mL), degassed with nitrogen, 5% Pd/C was added and the reaction was charged to 55 PSI hydrogen. The reaction was shaken for 6 h. The catalyst was removed over Celite and the filtrate was concentrated to give methyl 4-(1,1-dioxido-3,4-dihydro-2H-1-benzothiopyran-4-yl)benzoate (0.49 g, 73%) as a solid.

後処理

  1. customdegassed with nitrogen, 5% Pd/C
  2. additionwas added
  3. additionthe reaction was charged to 55 PSI hydrogen
  4. customThe catalyst was removed over Celite
  5. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-6df677ffe69641eca8ee55a9d9515fa8
出典データセット
uspto-grants-2004_04
特許番号
US06720329B2

反応ノート

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