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Diethyl Ether → 1-(2-Bromo-phenyl)-heptan-1-ol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diethyl Ether | HCID 3283 | — |
| 反応物 | Tetrahydrofuran | HCID 8028 | — |
| 反応物 | 2-Bromobenzaldehyde | HCID 81129 | — |
| 反応物 | HCID 178444609 | HCID 178444609 | — |
| 溶媒 | Hexane | HCID 8058 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | 1-(2-Bromo-phenyl)-heptan-1-ol | HCID 22731273 | — |
反応手順
Following General Procedure K and using 2-bromo-benzaldehyde (1.5 g, 8 mmol), 15 mL of anhydrous tetrahydrofuran, and a 2M solution of n-hexyl magnesium bromide solution in ether (6 mL, 12 mmol) followed by flash column chromatography using 10% ethyl acetate in hexane, the title compound was obtained (1.86 g, 85%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06720423B2 |
| 出典データセット | uspto-grants-2004_04 |
| ORD ID | ord-393e82db8a8c4988ba6d5b36ac145e2c |
| 出典メモ | uspto-grants-2004_04 |