Phosphorus oxychloride → Methyl 4-(6-chloropyridin-3-yl)benzoate

HRID 2085754ノート

反応式

HRID 2085754 の反応式
O[C:2]1[N:7]=[CH:6][C:5]([C:8]2[CH:17]=[CH:16][C:11]([C:12]([O:14][CH3:15])=[O:13])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.O=P(Cl)(Cl)[Cl:20]>>[Cl:20][C:2]1[N:7]=[CH:6][C:5]([C:8]2[CH:17]=[CH:16][C:11]([C:12]([O:14][CH3:15])=[O:13])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1

参加物

3

反応物 2

HCID 24813Phosphorus oxychlorideHCID 178497536HCID 178497536、化合物

生成物 1

HCID 22730372Methyl 4-(6-chloropyridin-3-yl)benzoate

実験手順

A solution of Example 252E (1.2 g, 5 mmol) in POCl3 (30 mL) was heated to reflux for 30 minutes. The excess POCl3 was removed under vacuum and the remaining product was purified by flash column chromatography on silica gel with 4:1 ethyl acetate/hexanes to provide the desired product. MS (ESI) m/e 248 (M+H)+.

後処理

  1. temperatureto reflux for 30 minutes
  2. customThe excess POCl3 was removed under vacuum
  3. customthe remaining product was purified by flash column chromatography on silica gel with 4:1 ethyl acetate/hexanes

出典と根拠

ORDレコード
ord-494e7f6cc3fa402c97ffea2470cd1cbb
出典データセット
uspto-grants-2004_04
特許番号
US06720338B2

反応ノート

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