Triethylamine → HCID 135817474、化合物

HRID 2086104ノート

反応式

HRID 2086104 の反応式
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:10][C:9]([C:11]3[CH:16]=[C:15]([Cl:17])[CH:14]=[CH:13][C:12]=3[OH:18])=[N:8][C:7](=O)[C:6]=2[CH:20]=1.Cl.[CH3:22][N:23]([CH3:33])[C:24]1[CH:32]=[CH:31][C:27]([CH2:28][NH:29][NH2:30])=[CH:26][CH:25]=1.C(N(CC)CC)C>C(O)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([OH:10])=[C:6]([C:7]2[N:8]=[C:9]([C:11]3[CH:16]=[C:15]([Cl:17])[CH:14]=[CH:13][C:12]=3[OH:18])[N:29]([CH2:28][C:27]3[CH:31]=[CH:32][C:24]([N:23]([CH3:33])[CH3:22])=[CH:25][CH:26]=3)[N:30]=2)[CH:20]=1

参加物

5

反応物 3

HCID 8471TriethylamineHCID 227280954-(Hydrazinylmethyl)-N,N-dimethylaniline--hydrogen chloride (1/1)HCID 135817451HCID 135817451、化合物

生成物 1

HCID 135817474HCID 135817474、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

3.0 g of 6-chloro-2-(5-chloro-2-hydroxyphenyl)benz[e][1,3]oxazin-4-one are boiled under reflux for 4 h with 2.2 g of 4-dimethylaminobenzylhydrazine hydrochloride and 3 ml of triethylamine in 50 ml of ethanol. The crystals precipitating on cooling are washed with ethanol. After drying, 3,5-bis(5-chloro-2-hydroxyphenyl)-1-(4-dimethylaminobenzyl)-1H-[1,2,4]triazole remains as colorless crystals of m.p. 205-207 C.

後処理

  1. customThe crystals precipitating
  2. temperatureon cooling
  3. washare washed with ethanol
  4. customAfter drying

出典と根拠

ORDレコード
ord-845e52e935ff4b598aafc94229081d36
出典データセット
uspto-grants-2004_04
特許番号
US06723742B2

反応ノート

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