Hydrochloric Acid → 4-(6-Chloronaphthalene-2-sulfonyl)-1-[methyl(4-piperidinyl)amino]-2-piperazinone hydrochloride

HRID 2086243ノート

反応式

HRID 2086243 の反応式
C(OC(N1CCCCC1[CH2:14][NH:15][N:16]1[CH2:21][CH2:20][N:19]([S:22]([C:25]2[CH:34]=[CH:33][C:32]3[C:27](=[CH:28][CH:29]=[C:30]([Cl:35])[CH:31]=3)[CH:26]=2)(=[O:24])=[O:23])[CH2:18][C:17]1=[O:36])=O)(C)(C)C.Cl.C(O[CH2:42][CH3:43])(=O)C>CO>[ClH:35].[Cl:35][C:30]1[CH:31]=[C:32]2[C:27](=[CH:28][CH:29]=1)[CH:26]=[C:25]([S:22]([N:19]1[CH2:20][CH2:21][N:16]([N:15]([CH3:14])[CH:43]3[CH2:42][CH2:21][NH:16][CH2:17][CH2:18]3)[C:17](=[O:36])[CH2:18]1)(=[O:24])=[O:23])[CH:34]=[CH:33]2

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 8857Ethyl Acetate2 回HCID 695455571-{[1-(Tert-butoxycarbonyl)piperidinyl]methylamino}-4-(6-chloronaphthalene-2-sulfonyl)-2-piperazinone

生成物 1

HCID 227272334-(6-Chloronaphthalene-2-sulfonyl)-1-[methyl(4-piperidinyl)amino]-2-piperazinone hydrochloride

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A suspension of 1-{[1-(tert-butoxycarbonyl)piperidinyl]methylamino}-4-(6-chloronaphthalene-2-sulfonyl)-2-piperazinone (10.42 g) in methanol (40 ml) was combined with a 4N solution of hydrochloric acid in ethyl acetate (20 ml) and stirred at room temperature for 5 hours. The reaction mixture was combined with ethyl acetate (50 ml) and the crystals precipitated were collected by filtration, dried to obtain the title compound (9.21 g) as colorless crystals.

後処理

  1. customthe crystals precipitated
  2. filtrationwere collected by filtration
  3. customdried

出典と根拠

ORDレコード
ord-0884c1b9927e412dbdeffe76aca42517
出典データセット
uspto-grants-2004_04
特許番号
US06723722B1

反応ノート

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