Sodium Methoxide → 4-Chloro-2-methoxymethylpyridine

HRID 2086257ノート

反応式

HRID 2086257 の反応式
Cl.[Cl:2][C:3]1[CH:8]=[CH:7][N:6]=[C:5]([CH2:9]Cl)[CH:4]=1.[CH3:11][O-:12].[Na+]>CO>[Cl:2][C:3]1[CH:8]=[CH:7][N:6]=[C:5]([CH2:9][O:12][CH3:11])[CH:4]=1

参加物

4

反応物 2

HCID 10942334Sodium MethoxideHCID 227272744-Chloro-2-(chloromethyl)pyridine--hydrogen chloride (1/1)

生成物 1

HCID 227270924-Chloro-2-methoxymethylpyridine収率 82%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
70 °C

実験手順

A mixture of 4-chloro-2-chloromethylpyridine hydrochloride (0.43 g), sodium methoxide (1.11 g) and methanol (15 ml) was stirred at room temperature for 10 hours and at 70° C. for 7 hours. The reaction mixture was concentrated, and the residue was combined with water and methylene chloride, and the organic phase was separated. After washing with saturated aqueous sodium bicarbonate followed by drying and concentrating, a title compound (0.28 g) was obtained as a tan oil.

後処理

  1. concentrationThe reaction mixture was concentrated
  2. customthe organic phase was separated
  3. washAfter washing with saturated aqueous sodium bicarbonate
  4. customby drying
  5. concentrationconcentrating

出典と根拠

ORDレコード
ord-01b252892f29416aba673e6e2f47436c
出典データセット
uspto-grants-2004_04
特許番号
US06723722B1

反応ノート

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