化工社化工社 化学情報印刷レポート · 研究参考用
Thionyl Chloride → 3-Dichloromethylthio-7-fluoro-1-methyl-4-quinolone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | 3-Chloromethylsulfinyl-7-fluoro-1-methyl-4-quinolone | HCID 10468547 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 生成物 | 3-Dichloromethylthio-7-fluoro-1-methyl-4-quinolone | HCID 11323779 | — |
反応手順
To an efficiently stirred and gently cooled 4.2 ml mixture of thionyl chloride (“SOCl2”) and 1.05 ml of pyridine (“Py”) at −3° C. was added 1.015 g (3.708 mmol) of 3-chloromethylsulfinyl-7-fluoro-1-methyl-4-quinolone (monochloroflosequinan)(Compound 1 of FIG. 1). This addition was made in multiple alloquots over a period of approximately 1 min. During this addition, cooling was applied to keep the temperature in the range 0-5° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06727262B2 |
| 出典データセット | uspto-grants-2004_04 |
| ORD ID | ord-273d39b67d384f8d85969decde7520cd |
| 出典メモ | uspto-grants-2004_04 |