Hydrazine, 1-naphthalenyl-, hydrochloride (1:1) → N-[3-(1-{3-[2-(2-Fluorophenyl)-1H-benzo[G]indol-3-YL]propyl}-4-piperidinyl)phenyl]-2-methylpropanamide

HRID 2087852ノート

反応式

HRID 2087852 の反応式
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=O)[CH2:9][CH2:10][CH2:11][CH2:12][N:13]1[CH2:18][CH2:17][CH:16]([C:19]2[CH:20]=[C:21]([NH:25][C:26](=[O:30])[CH:27]([CH3:29])[CH3:28])[CH:22]=[CH:23][CH:24]=2)[CH2:15][CH2:14]1.Cl.[C:33]1([NH:43]N)[C:42]2[C:37](=[CH:38][CH:39]=[CH:40][CH:41]=2)[CH:36]=[CH:35][CH:34]=1>>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[NH:43][C:33]2[C:34]([C:9]=1[CH2:10][CH2:11][CH2:12][N:13]1[CH2:18][CH2:17][CH:16]([C:19]3[CH:20]=[C:21]([NH:25][C:26](=[O:30])[CH:27]([CH3:29])[CH3:28])[CH:22]=[CH:23][CH:24]=3)[CH2:15][CH2:14]1)=[CH:35][CH:36]=[C:37]1[CH:38]=[CH:39][CH:40]=[CH:41][C:42]=21

参加物

3

反応物 2

HCID 519949Hydrazine, 1-naphthalenyl-, hydrochloride (1:1)HCID 22049199N-(3-{1-(5-(2-fluorophenyl)-5-oxopentyl]-4-piperidinyl}phenyl)-2-methylpropanamide

生成物 1

HCID 22049555N-[3-(1-{3-[2-(2-Fluorophenyl)-1H-benzo[G]indol-3-YL]propyl}-4-piperidinyl)phenyl]-2-methylpropanamide

実験手順

Prepared by Procedure E and Scheme M using N-(3-{1-[5-(2-fluorophenyl)-5-oxopentyl]-4-piperidinyl}phenyl)-2-methylpropanamide and 1-naphthylhydrazine hydrochloride: ESMS m/e: 547.7 (M+H)+.

後処理

  1. customPrepared by Procedure E and Scheme M

出典と根拠

ORDレコード
ord-6cc0ee4595f7436890520f32c23543a0
出典データセット
uspto-grants-2004_04
特許番号
US06727264B1

反応ノート

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