N-methyl-N-phenyl-hydrazine → N-[3-(1-{3-[2-(2-Fluorophenyl)-1-methyl-1H-indol-3-YL]propyl}-4-piperidinyl)phenyl]-2-methylpropanamide

HRID 2087864ノート

反応式

HRID 2087864 の反応式
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=O)[CH2:9][CH2:10][CH2:11][CH2:12][N:13]1[CH2:18][CH2:17][CH:16]([C:19]2[CH:20]=[C:21]([NH:25][C:26](=[O:30])[CH:27]([CH3:29])[CH3:28])[CH:22]=[CH:23][CH:24]=2)[CH2:15][CH2:14]1.[CH3:32][N:33]([C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1)N>>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[N:33]([CH3:32])[C:35]2[C:40]([C:9]=1[CH2:10][CH2:11][CH2:12][N:13]1[CH2:18][CH2:17][CH:16]([C:19]3[CH:20]=[C:21]([NH:25][C:26](=[O:30])[CH:27]([CH3:29])[CH3:28])[CH:22]=[CH:23][CH:24]=3)[CH2:15][CH2:14]1)=[CH:39][CH:38]=[CH:37][CH:36]=2

参加物

3

反応物 2

HCID 36299N-methyl-N-phenyl-hydrazineHCID 22049199N-(3-{1-(5-(2-fluorophenyl)-5-oxopentyl]-4-piperidinyl}phenyl)-2-methylpropanamide

生成物 1

HCID 22049356N-[3-(1-{3-[2-(2-Fluorophenyl)-1-methyl-1H-indol-3-YL]propyl}-4-piperidinyl)phenyl]-2-methylpropanamide

実験手順

Prepared by Procedure E and Scheme M using N-(3-{1-[5-(2-fluorophenyl)-5-oxopentyl]-4-piperidinyl}phenyl)-2-methylpropanamide and 1-methyl-1-phenylhydrazine: ESMS m/e: 512.2 (M+H)+.

後処理

  1. customPrepared by Procedure E and Scheme M

出典と根拠

ORDレコード
ord-d1ec274e041b490390317905bf4be44e
出典データセット
uspto-grants-2004_04
特許番号
US06727264B1

反応ノート

読み込み中…