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4-Bromophenacyl bromide → N-[4-(4-Bromo-phenyl)-1H-imidazol-2-yl]-acetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Bromophenacyl bromide | HCID 7454 | — |
| 反応物 | HCID 178475102 | HCID 178475102 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | N-[4-(4-Bromo-phenyl)-1H-imidazol-2-yl]-acetamide | HCID 10468856 | — |
反応手順
A mixture of 2-bromo-1-(4-bromophenyl)ethanone (2.00 g, 7.20 mmol) and acetylguanidine (2.18 g, 21.6 mmol) in DMF (40 mL) was stirred at rt for 48 h. The solution was concentrated to dryness in vacuo and the resulting brown solid was of sufficient purity for use in the next step. LCMS: Anal. Calcd. for C11H10BrN3O: 279, 281; found: 280, 282 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07745636B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-9095334553934822abb0be22ce7699c7 |
| 出典メモ | uspto-grants-2010_06 |