Hydrochloric Acid → HCID 66911325、化合物

HRID 2088647ノート

反応式

HRID 2088647 の反応式
C(OC(=O)[NH:7][CH2:8][CH2:9][NH:10][C:11]1[CH:16]=[CH:15][C:14]([C:17]#[N:18])=[C:13]([NH2:19])[N:12]=1)(C)(C)C.[ClH:21]>O1CCOCC1>[ClH:21].[ClH:21].[NH2:19][C:13]1[C:14]([C:17]#[N:18])=[CH:15][CH:16]=[C:11]([NH:10][CH2:9][CH2:8][NH2:7])[N:12]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 57911763tert-Butyl{2-[(6-amino-5-cyanopyridin-2-yl)amino]ethyl}carbamate

生成物 1

HCID 66911325HCID 66911325、化合物

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

6.76 g (24.38 mmol) of tert-butyl{2-[(6-amino-5-cyanopyridin-2-yl)amino]ethyl}carbamate (Example 8A) were dissolved in 122 ml of a 4 N solution of hydrogen chloride in dioxane and stirred for 30 min. The reaction mixture was concentrated to half of its original volume, and the same amount of diethyl ether was added. The reaction mixture was stirred for 20 min, and the product was filtered off and washed with diethyl ether. This gave 5.43 g (89% of theory) of the product as a solid.

後処理

  1. concentrationThe reaction mixture was concentrated to half of its original volume
  2. additionthe same amount of diethyl ether was added
  3. stirringThe reaction mixture was stirred for 20 min
  4. filtrationthe product was filtered off
  5. washwashed with diethyl ether

出典と根拠

ORDレコード
ord-8344ac32b4244f1bab7477a441cff26c
出典データセット
uspto-grants-2013_05
特許番号
US08436003B2

反応ノート

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