Hydrochloric Acid → HCID 67228737、化合物

HRID 2088662ノート

反応式

HRID 2088662 の反応式
C(OC(=O)[NH:7][C:8]1[C:13]([C:14](=[O:17])[CH2:15][CH3:16])=[CH:12][CH:11]=[C:10]([NH:18][CH2:19][CH2:20][NH:21]C(OC(C)(C)C)=O)[N:9]=1)(C)(C)C.[ClH:30]>O1CCOCC1.C(OCC)C>[ClH:30].[NH2:7][C:8]1[C:13]([C:14](=[O:17])[CH2:15][CH3:16])=[CH:12][CH:11]=[C:10]([NH:18][CH2:19][CH2:20][NH2:21])[N:9]=1

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 57911744tert-Butyl[6-({2-[(tert-butoxycarbonyl)amino]ethyl}amino)-3-propanoylpyridin-2-yl]carbamate

生成物 1

HCID 67228737HCID 67228737、化合物

試薬・触媒・溶媒 2

HCID 3283Diethyl Ether溶媒HCID 312751,4-Dioxane溶媒

実験手順

530 mg (1.30 mmol) of tert-butyl[6-({2-[(tert-butoxycarbonyl)amino]ethyl}amino)-3-propanoylpyridin-2-yl]carbamate (Example 24A) were dissolved in 15 ml of a solution of hydrochloric acid in dioxane (4 M), and the mixture was stirred at RT for 20 h. After the reaction had gone to completion, the reaction mixture was diluted with diethyl ether (100 ml), and the precipitate was filtered off, washed with diethyl ether (100 ml) and dried. This gave 290 mg (91% of theory) of the product as a solid.

後処理

  1. filtrationthe precipitate was filtered off
  2. washwashed with diethyl ether (100 ml)
  3. customdried

出典と根拠

ORDレコード
ord-d6a3e4019908441b8c8ff6319398847d
出典データセット
uspto-grants-2013_05
特許番号
US08436003B2

反応ノート

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