HCID 18382547、化合物 → HCID 178425045、化合物
反応式
[CH3:1][N:2]1[CH2:11][C:10](C)(C)[C:9]2[C:4](=[CH:5][C:6]([NH2:14])=[CH:7][CH:8]=2)[CH2:3]1.Cl[C:16]1[N:21]=[C:20]2[NH:22][C:23](=[O:35])[N:24]([C:27]3[C:32]([CH3:33])=[CH:31][CH:30]=[CH:29][C:28]=3[Cl:34])[C:25](=[NH:26])[C:19]2=[CH:18][N:17]=1.ClC1N=C2NC(=O)N(C3C(Cl)=CC=CC=3Cl)C(=N)C2=CN=1>>[Cl:34][C:28]1[CH:29]=[CH:30][CH:31]=[C:32]([CH3:33])[C:27]=1[N:24]1[C:25](=[NH:26])[C:19]2[C:20](=[N:21][C:16]([NH:14][C:6]3[CH:5]=[C:4]4[C:9]([CH2:10][CH2:11][N:2]([CH3:1])[CH2:3]4)=[CH:8][CH:7]=3)=[N:17][CH:18]=2)[NH:22][C:23]1=[O:35]参加物
4
実験手順
35 mg of the entitled compound was obtained as a white solid according to the same method as in Example 2, for which, however, 2-methyl-1,2,3,4-tetrahydroisoquinolin-7-amine obtained in Production Example 22 was used in place of 2,4,4-trimethyl-1,2,3,4-tetrahydroisoquinolin-7-amine in Example 2, and 7-chloro-3-(2-chloro-6-methylphenyl)-4-imino-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one obtained in Production Example 2 was used in place of 7-chloro-3-(2,6-dichlorophenyl)-4-imino-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one.