Hydrochloric Acid → 4-(4-Bromo-1-(2-(pyrrolidin-1-yl)ethyl)-1H-imidazol-2-yl)piperidine trihydrochloride

HRID 2088896ノート

反応式

HRID 2088896 の反応式
[Br:1][C:2]1[N:3]=[C:4]([CH:14]2[CH2:19][CH2:18][N:17](C(OC(C)(C)C)=O)[CH2:16][CH2:15]2)[N:5]([CH2:7][CH2:8][N:9]2[CH2:13][CH2:12][CH2:11][CH2:10]2)[CH:6]=1.[Cl:27]CCl.[ClH:30].O1CCOCC1>CO>[ClH:27].[ClH:30].[ClH:27].[Br:1][C:2]1[N:3]=[C:4]([CH:14]2[CH2:15][CH2:16][NH:17][CH2:18][CH2:19]2)[N:5]([CH2:7][CH2:8][N:9]2[CH2:10][CH2:11][CH2:12][CH2:13]2)[CH:6]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 6344DichloromethaneHCID 312751,4-DioxaneHCID 67112012tert-Butyl 4-(4-bromo-1-(2-(pyrrolidin-1-yl)ethyl)-1H-imidazol-2-yl)piperidine-1-carboxylate

生成物 1

HCID 671132564-(4-Bromo-1-(2-(pyrrolidin-1-yl)ethyl)-1H-imidazol-2-yl)piperidine trihydrochloride収率 100%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Combine tert-butyl 4-(4-bromo-1-(2-(pyrrolidin-1-yl)ethyl)-1H-imidazol-2-yl)piperidine-1-carboxylate (0.80 g, 1.87 mmol), dichloromethane (20 mL), methanol (8 mL), and 4M hydrochloric acid in dioxane (9.36 mL, 20.0 eq) under nitrogen and let stir at room temperature. After 1.5 hours, concentrate in vacuo to give the title compound (0.82 g, 100%). MS (ES) m/z=327 [M]+.

後処理

  1. concentrationconcentrate in vacuo

出典と根拠

ORDレコード
ord-b00fd3d1503b4ac1aa0b06e862cffb3c
出典データセット
uspto-grants-2013_05
特許番号
US08436002B2

反応ノート

読み込み中…