Methylhydrazine → 3(2H)-Pyridazinone, 6-(4-chlorophenyl)-4,5-dihydro-2-methyl-

HRID 2089

反応式

HRID 2089 の反応式
[Cl:1][C:2]1[CH:14]=[CH:13][C:5]([C:6]([CH2:8][CH2:9][C:10](O)=[O:11])=O)=[CH:4][CH:3]=1.[CH3:15][NH:16][NH2:17]>C(O)C>[Cl:1][C:2]1[CH:14]=[CH:13][C:5]([C:6]2[CH2:8][CH2:9][C:10](=[O:11])[N:16]([CH3:15])[N:17]=2)=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 6061MethylhydrazineHCID 776043-(4-Chlorobenzoyl)propionic acid

生成物 1

HCID 121965643(2H)-Pyridazinone, 6-(4-chlorophenyl)-4,5-dihydro-2-methyl-

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a 250 ml flask equipped with magnetic stirrer and reflux condenser was charged 10 g of 3-(4-chlorobenzoyl)-propionic acid, 250 ml of absolute ethanol, and 2.5 ml of methyl hydrazine. The reaction was refluxed for 3 hours and cooled to yield a solid which was collected by vacuum filtration, washed with 50 ml of hexane, and air dried. Isolated 9.5 g of product as a white solid.

後処理

  1. customTo a 250 ml flask equipped with magnetic stirrer
  2. temperaturereflux condenser
  3. temperatureThe reaction was refluxed for 3 hours
  4. temperaturecooled
  5. customto yield a solid which
  6. filtrationwas collected by vacuum filtration
  7. washwashed with 50 ml of hexane, and air
  8. customdried

出典と根拠

ORDレコード
ord-86a6b338addf413b9e8f29662d8d58d4
出典データセット
uspto-grants-1998_03
特許番号
US05728694

関連ノート

読み込み中…