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Triethylamine → N-(3-(6-chloro-4-iodopyridin-2-ylamino)cyclohexyl)-2-(1,3-dioxoisoindolin-2-yl)ethanesulfonamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 2-Phthalimidoethanesulfonyl chloride | HCID 308739 | — |
| 反応物 | N1-(6-chloro-4-iodopyridin-2-yl)cyclohexane-1,3-diamine | HCID 86649873 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | N-(3-(6-chloro-4-iodopyridin-2-ylamino)cyclohexyl)-2-(1,3-dioxoisoindolin-2-yl)ethanesulfonamide | HCID 87192629 | — |
反応手順
To a solution of Example 145a (280 mg, 0.8 mmol) in CH2Cl2 (10 mL) was added triethylamine (110 mg, 1 mmol) and followed by 2-(1,3-dioxoisoindolin-2-yl)ethanesulfonyl chloride (262 mg, 0.95 mmol). The mixture was stirred at room temperature overnight. The reaction mixture was concentrated and the residue was purified by flash chromophatography (EtOAc/hexanes=1:4) to give the title compound. Yield: 180 mg (32%). MS (DCI/NH3) m/z 589 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08435980B2 |
| 出典データセット | uspto-grants-2013_05 |
| ORD ID | ord-b2c476efba3c49d692f80289dff4f3d9 |
| 出典メモ | uspto-grants-2013_05 |