Potassium Hydroxide → 3-(2,6-Dichloro-4-pyridinyl)-5-methoxy-1H-pyrrolo[2,3-b]pyridine

HRID 2089018

反応式

HRID 2089018 の反応式
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]2[C:16]3[C:11](=[N:12][CH:13]=[C:14]([O:17][CH3:18])[CH:15]=3)[N:10](S(C3C=CC=CC=3)(=O)=O)[CH:9]=2)[CH:5]=[C:4]([Cl:28])[N:3]=1.[OH-].[K+]>C(O)C.O>[Cl:1][C:2]1[CH:7]=[C:6]([C:8]2[C:16]3[C:11](=[N:12][CH:13]=[C:14]([O:17][CH3:18])[CH:15]=3)[NH:10][CH:9]=2)[CH:5]=[C:4]([Cl:28])[N:3]=1

参加物

5

反応物 2

HCID 14797Potassium HydroxideHCID 871925543-(2,6-dichloropyridin-4-yl)-5-methoxy-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine

生成物 1

HCID 871921833-(2,6-Dichloro-4-pyridinyl)-5-methoxy-1H-pyrrolo[2,3-b]pyridine収率 85.9%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

反応条件

温度
50 °C

実験手順

A suspension of Example 149d (88.0 mg, 0.203 mmol) in ethanol (2 mL) was treated with a solution of potassium hydroxide (45.5 mg, 0.811 mmol) in water (0.5 mL). The reaction mixture was heated at 50° C. for 1.5 hours. After concentration, water was added to the residue and the mixture was sonicated. The solid was filtered, washed with water, and oven-dried to give 51.3 mg of the title compound.

後処理

  1. concentrationAfter concentration, water
  2. additionwas added to the residue
  3. customthe mixture was sonicated
  4. filtrationThe solid was filtered
  5. washwashed with water
  6. customoven-dried

出典と根拠

ORDレコード
ord-e69bb49baf794e34b733545ae9b2740b
出典データセット
uspto-grants-2013_05
特許番号
US08435980B2

関連ノート

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