1,3-Cyclohexanediamine → N1-(6-chloro-4-iodopyridin-2-yl)cyclohexane-1,3-diamine

関与物質

反応条件

反応手順

A mixture of 2,6-dichloro-4-iodopyridine (2.500 g, 9.13 mmol) and cyclohexane-1,3-diamine (4.44 mL, 36.5 mmol) was heated at 120° C. in a capped vial for 2 hours. While warm, the reaction mixture was treated with EtOAc and washed with water (3×). The organic layer was dried and concentrated to give 2.62 g of the crude title compound. This material was carried into the next step without further purification.

情報源と証拠