Water → 2-methyl-2,3,5,6,7,8-hexahydro-1H-cyclopenta[b]naphthalen-1-one

HRID 2089085ノート

反応式

HRID 2089085 の反応式
[CH:1]1[CH2:2][C:3](=O)[CH:4]=[C:5]2[C:10]=1[CH:9]=[CH:8][CH:7]=[CH:6]2.[OH2:12]>>[CH3:4][CH:5]1[C:10](=[O:12])[C:2]2=[CH:1][C:10]3[CH2:9][CH2:8][CH2:7][CH2:6][C:5]=3[CH:4]=[C:3]2[CH2:6]1

参加物

3

反応物 2

HCID 962WaterHCID 20192716Naphthalen-3-one

生成物 1

HCID 224992222-methyl-2,3,5,6,7,8-hexahydro-1H-cyclopenta[b]naphthalen-1-one

実験手順

The reaction is diluted with water and extracted with dichloromethane. After drying (Na2SO4) the solvent is removed to give an oil. The product is purified by chromatography (silica, ethyl acetate/hexane) to give a geometrical mixture of isomers containing 2-Methyl-1,2,6,7,8,9-hexahydro-cyclopenta[.a.]naphthalen-3-one and the title compound.

後処理

  1. extractionextracted with dichloromethane
  2. dry with materialAfter drying (Na2SO4) the solvent
  3. customis removed
  4. customto give an oil
  5. customThe product is purified by chromatography (silica, ethyl acetate/hexane)
  6. customto give
  7. additiona geometrical mixture of isomers
  8. additioncontaining 2-Methyl-1,2,6,7,8,9-hexahydro-cyclopenta[.a

出典と根拠

ORDレコード
ord-f6363a541244451d9f99629d4227ec76
出典データセット
uspto-grants-2013_05
特許番号
US08436017B2

反応ノート

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