4-(tert-Butyldimethylsilyloxy)cyclohexanone → N-{1-[4-(tert-Butyl-dimethyl-silanyloxy)-cyclohexyl]-azetidin-3-yl}-2-(5-trifluoromethyl-benzo[d]isoxazol-3-ylamino)-acetamide

HRID 2089139

反応式

HRID 2089139 の反応式
OC(C(F)(F)F)=O.[NH:8]1[CH2:11][CH:10]([NH:12][C:13](=[O:29])[CH2:14][NH:15][C:16]2[C:20]3[CH:21]=[C:22]([C:25]([F:28])([F:27])[F:26])[CH:23]=[CH:24][C:19]=3[O:18][N:17]=2)[CH2:9]1.[C:30]([Si:34]([CH3:44])([CH3:43])[O:35][CH:36]1[CH2:41][CH2:40][C:39](=O)[CH2:38][CH2:37]1)([CH3:33])([CH3:32])[CH3:31]>>[C:30]([Si:34]([CH3:44])([CH3:43])[O:35][CH:36]1[CH2:41][CH2:40][CH:39]([N:8]2[CH2:11][CH:10]([NH:12][C:13](=[O:29])[CH2:14][NH:15][C:16]3[C:20]4[CH:21]=[C:22]([C:25]([F:27])([F:26])[F:28])[CH:23]=[CH:24][C:19]=4[O:18][N:17]=3)[CH2:9]2)[CH2:38][CH2:37]1)([CH3:33])([CH3:32])[CH3:31]

参加物

3

反応物 2

HCID 106094304-(tert-Butyldimethylsilyloxy)cyclohexanoneHCID 86660176HCID 86660176、化合物

生成物 1

HCID 58548829N-{1-[4-(tert-Butyl-dimethyl-silanyloxy)-cyclohexyl]-azetidin-3-yl}-2-(5-trifluoromethyl-benzo[d]isoxazol-3-ylamino)-acetamide

実験手順

The title compound was prepared as a white solid from reaction of (N-azetidin-3-yl-2-(5-trifluoromethyl-benzo[d]isoxazol-3-ylamino)-acetamide TFA salt (as prepared in Example 1, Step D) and 4-(tert-butyl-dimethyl-silanyloxy)-cyclohexanone using the procedure described in Step E of Example 1.

出典と根拠

ORDレコード
ord-dd5ad6d98f844a1eb99a60ee5647a9ca
出典データセット
uspto-grants-2013_05
特許番号
US08436023B2

関連ノート

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