Glyoxylic Acid → (1-Methyl-5-trifluoromethyl-1H-indazol-3-ylamino)-acetic acid

反応式

[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][C:7]([C:11]([F:14])([F:13])[F:12])=[CH:8][CH:9]=2)[C:4]([NH2:15])=[N:3]1.[C:16]([OH:20])(=[O:19])[CH:17]=O>>[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][C:7]([C:11]([F:12])([F:13])[F:14])=[CH:8][CH:9]=2)[C:4]([NH:15][CH2:17][C:16]([OH:20])=[O:19])=[N:3]1

参加物

反応物 2

HCID 760Glyoxylic Acid

HCID 288753771-Methyl-5-(trifluoromethyl)-1H-indazol-3-amine

生成物 1

HCID 67478753(1-Methyl-5-trifluoromethyl-1H-indazol-3-ylamino)-acetic acid

実験手順

The title compound was prepared as white solid from reductive amination of 1-methyl-5-trifluoromethyl-1H-indazol-3-ylamine (as prepared in the previous step) and glyoxylic acid using the procedure described in Step B of Example 1.

出典と根拠

ORDレコード: ord-8293e9c914924dd5a2f77887b30b5deb
出典データセット: uspto-grants-2013_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08436023B2

反応ノート

読み込み中…