Ammonia → 2-Chloro-5-(trifluoromethyl)nicotinamide
反応式
[NH3:1].[Cl:2][C:3]1[N:11]=[CH:10][C:9]([C:12]([F:15])([F:14])[F:13])=[CH:8][C:4]=1[C:5](Cl)=[O:6]>O.O1CCOCC1.C(OCC)(=O)C>[Cl:2][C:3]1[N:11]=[CH:10][C:9]([C:12]([F:15])([F:14])[F:13])=[CH:8][C:4]=1[C:5]([NH2:1])=[O:6]参加物
6
実験手順
An ice-cold solution of ammonia in water was treated with a solution of 2-chloro-5-(trifluoromethyl)nicotinoyl chloride (as prepared in the previous step, 1.18 g, 4.8 mmol) in dioxane. After stirring at ice bath temperature for 1 hour, the resulting precipitate was dissolved in ethyl acetate and the organic extract dried over anhydrous sodium sulfate. Concentration in vacuo followed by drying on the high vacuum afforded the product as a white solid.
後処理
- extractionthe organic extract
- dry with materialdried over anhydrous sodium sulfate
- concentrationConcentration in vacuo
- customby drying on the high vacuum
出典と根拠
- ORDレコード
- ord-4dd0051a5990483b917d9d99b0dde0f6
- 出典データセット
- uspto-grants-2013_05
- 特許番号
- US08436023B2
反応ノート
読み込み中…