1-methyl-1H-pyrazol-4-amine → 5-amino-N-(1-methyl-1H-pyrazol-4-yl)thiazole-4-carboxamide

反応式

[CH3:1][N:2]1[CH:6]=[C:5]([NH2:7])[CH:4]=[N:3]1.C(OC([NH:15][C:16]1[S:20][CH:19]=[N:18][C:17]=1[C:21](O)=[O:22])=O)(C)(C)C>>[NH2:15][C:16]1[S:20][CH:19]=[N:18][C:17]=1[C:21]([NH:7][C:5]1[CH:4]=[N:3][N:2]([CH3:1])[CH:6]=1)=[O:22]

参加物

反応物 2

HCID 47709901-methyl-1H-pyrazol-4-amine

HCID 581822035-(Boc-amino)-thiazole-4-carboxylic acid

生成物 1

HCID 674382945-amino-N-(1-methyl-1H-pyrazol-4-yl)thiazole-4-carboxamide収率 32%

実験手順

Following the procedures as described in Example 113, 1-methyl-1H-pyrazol-4-amine, 5-(tert-butoxycarbonylamino)thiazole-4-carboxylic acid were reacted to give 5-amino-N-(1-methyl-1H-pyrazol-4-yl)thiazole-4-carboxamide as a white solid (13 mg, 32%) over two steps. ESIMS m/z=336.1 (M+1)

後処理

customwere reacted

出典と根拠

ORDレコード: ord-063c7bd26a5f467c9c042d09a150aace
出典データセット: uspto-grants-2013_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08436001B2

反応ノート

読み込み中…

参加物