Dimethyl Sulfoxide → [1-amino(4-{[(R)-[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl](5-oxo-1-pyrimidin-2-yl-4,5-dihydro-1H-[1,2,4]-triazol-3-yl)methyl]amino}phenyl)methylene]carbamic acid 2-methylallyl ester

HRID 2089689

反応式

HRID 2089689 の反応式
CO[C@H](C1C=CC=CC=1)C(O)=O.[F:13][C:14]1[C:19]([O:20][CH2:21][CH2:22][OH:23])=[CH:18][C:17]([O:24][CH3:25])=[CH:16][C:15]=1[C@@H:26]([NH:39][C:40]1[CH:48]=[CH:47][C:43]([C:44]([NH2:46])=[NH:45])=[CH:42][CH:41]=1)[C:27]1[NH:31][C:30](=[O:32])[N:29]([C:33]2[N:38]=[CH:37][CH:36]=[CH:35][N:34]=2)[N:28]=1.C(=O)([O-])[O-].[K+].[K+].CS(C)=O.C1([O:65][C:66](=O)[O:67][CH2:68][C:69]([CH3:71])=[CH2:70])C=CC=CC=1>C(O)(=O)C.O.C(OCC)(=O)C>[CH3:71][C:69](=[CH2:70])[CH2:68][O:67][C:66](=[O:65])[N:45]=[C:44]([C:43]1[CH:42]=[CH:41][C:40]([NH:39][C@H:26]([C:15]2[CH:16]=[C:17]([O:24][CH3:25])[CH:18]=[C:19]([O:20][CH2:21][CH2:22][OH:23])[C:14]=2[F:13])[C:27]2[NH:31][C:30](=[O:32])[N:29]([C:33]3[N:34]=[CH:35][CH:36]=[CH:37][N:38]=3)[N:28]=2)=[CH:48][CH:47]=1)[NH2:46]

参加物

8

反応物 4

HCID 679Dimethyl SulfoxideHCID 11430Potassium CarbonateHCID 151790822-Methyl-allyl phenyl carbonateHCID 1363340344-{[(R)-[2-fluoro-3-(2-hy droxy ethoxy)-5-methoxyphenyl] (5-oxo-1-pyrimidi n-2-yl-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl]amino}benzamidine (R)-methoxyphenylacetate

生成物 1

HCID 136334036[1-amino(4-{[(R)-[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl](5-oxo-1-pyrimidin-2-yl-4,5-dihydro-1H-[1,2,4]-triazol-3-yl)methyl]amino}phenyl)methylene]carbamic acid 2-methylallyl ester

試薬・触媒・溶媒 3

HCID 176Acetic Acid溶媒HCID 962Water溶媒HCID 8857Ethyl Acetate溶媒

反応条件

温度
60 °C

実験手順

To a mixture of 4-{[(R)-[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl](5-oxo-1-pyrimidin-2-yl-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl]amino}benzamidine (R)-methoxyphenylacetate (0.5 g, 0.755 mmol), potassium carbonate (104 mg, 0.755 mmol), and dimethyl sulfoxide (1.5 mL), carbonic acid 2-methylallyl ester phenyl ester [CAS No. 138621-73-5] (145 mg, 0.755 mmol) was added, and the resulting mixture was stirred at 60° C. for 2 hours and 30 minutes. After cooling the mixture, the reaction solution was added to a mixture of ethyl acetate (5 mL) and water (15 mL), and an aqueous acetic acid solution (prepared from acetic acid (0.1 mL) and water (5 mL)) was added dropwise to the resulting mixture with stirring. The precipitated solid was filtered and sequentially washed with ethyl acetate (10 mL) and water (10 mL). The solid obtained was dried under air flow to obtain the captioned compound (361 mg) as a yellow solid.

後処理

  1. addition138621-73-5] (145 mg, 0.755 mmol) was added
  2. temperatureAfter cooling the mixture
  3. stirringwith stirring
  4. filtrationThe precipitated solid was filtered
  5. washsequentially washed with ethyl acetate (10 mL) and water (10 mL)
  6. customThe solid obtained
  7. customwas dried under air flow

出典と根拠

ORDレコード
ord-4dc6f673ba6646939261371be185efe3
出典データセット
uspto-grants-2013_05
特許番号
US08436009B2

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