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2-(4-Methylpiperazin-1-yl)pyridine-4-boronic acid, pinacol ester → 4-(4-Methylpiperazin-1-yl)-6-[7-[2-(4-methylpiperazin-1-yl)pyridin-4-yl]-3,4-dihydroisoquinolin-2(1H)-yl]pyrimidin-2-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-(4-Methylpiperazin-1-yl)pyridine-4-boronic acid, pinacol ester | HCID 2769537 | — |
| 反応物 | 4-(7-bromo-3,4-dihydroisoquinolin-2(1H)-yl)-6-(4-methylpiperazin-1-yl)pyrimidin-2-amine | HCID 46701048 | — |
| 生成物 | 4-(4-Methylpiperazin-1-yl)-6-[7-[2-(4-methylpiperazin-1-yl)pyridin-4-yl]-3,4-dihydroisoquinolin-2(1H)-yl]pyrimidin-2-amine | HCID 59402302 | — |
反応手順
This compound was prepared by using procedures analogous to those described for the synthesis of Example 2 starting from 4-(7-bromo-3,4-dihydroisoquinolin-2(1H)-yl)-6-(4-methylpiperazin-1-yl)pyrimidin-2-amine and 1-methyl-4-[4(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]piperazine (Oadwood, Cat. No. 021854). LCMS (M+H)+: m/z=500.5.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08436008B2 |
| 出典データセット | uspto-grants-2013_05 |
| ORD ID | ord-f77c56a60ce244b8a6de209918a5af26 |
| 出典メモ | uspto-grants-2013_05 |