Hydrochloric Acid → Isobutyric acid (1s,2s)-6-fluoro-2-[2-({3-[(2-fluoro-ethyl)-(3-methoxy-2-methoxymethyl-2-methyl-propyl)-amino]-propyl}-methyl-amino)-ethyl]-1-isopropyl-1,2,3,4-tetrahydro-naphthalen-2-yl ester dihydrochloride salt

HRID 2090574ノート

反応式

HRID 2090574 の反応式
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C@H:8]([CH:12]([CH3:14])[CH3:13])[C@@:7]([O:35][C:36](=[O:40])[CH:37]([CH3:39])[CH3:38])([CH2:15][CH2:16][N:17]([CH2:19][CH2:20][CH2:21][N:22]([CH2:32][CH2:33][F:34])[CH2:23][C:24]([CH2:29][O:30][CH3:31])([CH3:28])[CH2:25][O:26][CH3:27])[CH3:18])[CH2:6][CH2:5]2.[ClH:41]>CCOC(C)=O>[ClH:41].[ClH:41].[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C@H:8]([CH:12]([CH3:14])[CH3:13])[C@@:7]([O:35][C:36](=[O:40])[CH:37]([CH3:39])[CH3:38])([CH2:15][CH2:16][N:17]([CH2:19][CH2:20][CH2:21][N:22]([CH2:32][CH2:33][F:34])[CH2:23][C:24]([CH2:29][O:30][CH3:31])([CH3:28])[CH2:25][O:26][CH3:27])[CH3:18])[CH2:6][CH2:5]2

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 45381136isobutyric acid (1S,2S)-6-fluoro-2-[2-({3-[(2-fluoro-ethyl)-(3-methoxy-2-methoxymethyl-2-methyl-propyl)-amino]-propyl}-methyl-amino)-ethyl]-1-isopropyl-1,2,3,4-tetrahydro-naphthalen-2-yl ester

生成物 1

HCID 86657122Isobutyric acid (1s,2s)-6-fluoro-2-[2-({3-[(2-fluoro-ethyl)-(3-methoxy-2-methoxymethyl-2-methyl-propyl)-amino]-propyl}-methyl-amino)-ethyl]-1-isopropyl-1,2,3,4-tetrahydro-naphthalen-2-yl ester dihydrochloride salt

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

411 mg of isobutyric acid (1S,2S)-6-fluoro-2-[2-({3-[(2-fluoro-ethyl)-(3-methoxy-2-methoxymethyl-2-methyl-propyl)-amino]-propyl}-methyl-amino)-ethyl]-1-isopropyl-1,2,3,4-tetrahydro-naphthalen-2-yl ester were dissolved in 10 mL EtOAc, the solution was cooled with an ice bath and 2.4 mL of 3M HCl in EtOAC were added. The reaction mixture was evaporated to dryness without heating to give the desired isobutyric acid (1S,2S)-6-fluoro-2-[2-({3-[(2-fluoro-ethyl)-(3-methoxy-2-methoxymethyl-2-methyl-propyl)-amino]-propyl}-methyl-amino)-ethyl]-1-isopropyl-1,2,3,4-tetrahydro-naphthalen-2-yl ester dihydrochloride salt.

後処理

  1. temperaturethe solution was cooled with an ice bath
  2. customThe reaction mixture was evaporated to dryness
  3. temperaturewithout heating

出典と根拠

ORDレコード
ord-8d691f5156da42f4949101d52fe5495e
出典データセット
uspto-grants-2013_05
特許番号
US08436205B2

反応ノート

読み込み中…