化工社化工社 化学情報印刷レポート · 研究参考用
Sodium hydride → 1-(2-Chloropyrimidin-5-ylsulfonyl)-5-phenyl-1H-pyrrole-3-carbaldehyde
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 15-Crown-5 | HCID 36336 | — |
| 反応物 | 5-Phenyl-1H-pyrrole-3-carboxaldehyde | HCID 11052090 | — |
| 反応物 | 2-Chloropyrimidine-5-sulfonyl chloride | HCID 43244366 | — |
| 生成物 | 1-(2-Chloropyrimidin-5-ylsulfonyl)-5-phenyl-1H-pyrrole-3-carbaldehyde | HCID 86620758 | — |
反応手順
By a reaction under similar conditions as in Reference Example 55 and using 5-phenyl-1H-pyrrole-3-carbaldehyde (342 mg), sodium hydride (60% in oil, 120 mg), 15-crown-5 (0.60 mL) and 2-chloro-5-pyrimidinesulfonyl chloride (554 mg), the title compound was obtained as a yellow solid (yield 390 mg, 56%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08436187B2 |
| 出典データセット | uspto-grants-2013_05 |
| ORD ID | ord-331aa2e0777040e5905244e696de091e |
| 出典メモ | uspto-grants-2013_05 |