1,4-Dioxane hydrochloride → HCID 66989598、化合物

HRID 2091549ノート

反応式

HRID 2091549 の反応式
C(OC([NH:8][CH2:9][C:10]([O:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]2[C:20]([CH2:32][O:33][C:34]3[CH:39]=[C:38]([F:40])[CH:37]=[CH:36][C:35]=3[CH3:41])=[C:21]3[C:26](=[CH:27][CH:28]=2)[NH:25][C:24]([CH3:30])([CH3:29])[CH:23]=[C:22]3[CH3:31])=[C:15]([O:42][CH3:43])[CH:14]=1)=[O:11])=O)(C)(C)C.[ClH:44].O1CCOCC1>O1CCOCC1>[ClH:44].[NH2:8][CH2:9][C:10]([O:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]2[C:20]([CH2:32][O:33][C:34]3[CH:39]=[C:38]([F:40])[CH:37]=[CH:36][C:35]=3[CH3:41])=[C:21]3[C:26](=[CH:27][CH:28]=2)[NH:25][C:24]([CH3:30])([CH3:29])[CH:23]=[C:22]3[CH3:31])=[C:15]([O:42][CH3:43])[CH:14]=1)=[O:11]

参加物

4

反応物 2

HCID 204431481,4-Dioxane hydrochlorideHCID 24798769HCID 24798769、化合物

生成物 1

HCID 66989598HCID 66989598、化合物収率 98%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

6-(4-t-Butoxycarbonylaminoacetoxy-2-methoxyphenyl)-5-(5-fluoro-2-methylphenoxymethyl)-2,2,4-trimethyl-1,2-dihydroquinoline (Reference Compound No. 4-1, 20.1 mg, 0.034 mmol) was dissolved in 1,4-dioxane (0.5 mL), 4N hydrogen chloride/1,4-dioxane solution (34 μL) was added thereto, and then the mixture was stirred at room temperature overnight. The reaction mixture was concentrated under reduced pressure to give the titled compound (17.5 mg) as a colorless solid. (Yield 98%)

後処理

  1. concentrationThe reaction mixture was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-56a0f8b577244de692e6a3137511bb93
出典データセット
uspto-grants-2013_05
特許番号
US08440660B2

反応ノート

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